VitroGel High-Concentration Gel Series offers exceptional flexibility, allowing the mechanical strength of
the gel to be controlled from 10 Pa to 4000 Pa. VitroGel is modified with a variety of functional ligands, such as RGD, collagen (COL), laminin (IKVAV, YIGSR), and matrix metalloproteinases (MMP). This system enables the study of cell responses to individual functional ligands by freely mixing different versions and creating various gel combinations.
VitroGel® MMP HIGH CONCENTRATION is modified with metalloproteinases and can be degraded by various MMPs (MMP1, MMP2, MMP3, MMP9, and MMP13). It supports various biological activities such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and more.

MMP2 Enzyme Degradation of VitroGel® MMP
A) No dilution of VitroGel before adding MMP2 (1 µg/mL): Incubated for 24 hours at 37°C with 5% CO2 on a shaker at 40 rpm. After six days, degradation appeared in the middle of the gel.
B) VitroGel diluted 1:3 and MMP2 added: After 6 hours, VitroGel was almost completely degraded.
C) Rheological data shows that after adding MMP2, the elastic modulus of VitroGel in group B rapidly decreased over time.
D) Glioblastoma cells (SNB 75) cultured in 3D within VitroGel® MMP.